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High dose amoxicillin clavulanate for the treatment of acute otitis media in children

Taiwanese researchers conducted a retrospective cohort study, which examined the practice of prescribing antibiotics for acute otitis media (OTO), whether clear adherence to recommended dosage regimens improves the prognosis of OCO. This study, published in the Scientific World Journal, also attempted to identify possible factors that could influence the results in a CCA.

The study included data on 400 children with CCA. The amoxicillin dosing schedule was considered to comply with clinical recommendations in cases where the drug was used at a dose of 80 to 90 mg / kg / day. ACC results were determined based on the description of the local condition of the eardrum according to the patient's medical records. Multivariate logistic regression analysis was used to assess the possible relationship between the antibiotic regimen and the prognosis for TOC after correction of the initial factors.

The majority (89.1%) of the antibiotic prescriptions were found to correspond to the recommended dosing schedule, but this did not significantly affect the outcome (p = 0.41). The correlation between an insufficient (small) dose of amoxicillin and a poor prognosis was statistically significant in children weighing less than 20 kg with bilateral acute otitis media (odds ratio 1.63, 95% confidence interval 1.02 -2.59, p = 0.04).

Thus, the results of this retrospective study evaluating the dosing tactics of amoxicillin / clavulanate in children with acute otitis media have shown that the use of a high-dose form of the drug in accordance with current clinical recommendations exceeds generally accepted dosing schedules in patients weighing up to 20 kg and with bilateral relationships. otitis media.